Biqing ® (Sodium Valproate for Injection)

  • Product name: Biqing ®
  • Pharmacology category: Fatty acid antiepileptics
  • Generic name: Sodium Valproate for Injection
  • National list of emergency drugs, and class B product of national medical insurance

Indication indication

Indication indication
This product is used for treatment of epilepsy. Among the adults or children, when oral agents cannot be taken temporarily, this product will be used instead of oral agents.

Product advantage

Product advantage
  • Multiple-mechanism control of epilepsy

    Regulation γ-aminobutyric acid (GABA) energy system, ion channel

  • High safety

    Have no liver enzyme induction effect, and fewer side effects

  • Broad-spectrum resistance to epilepsy

    Control action in various epileptic diseases

  • Classic

    It has been launched in the domestic market for 30 years, with rich and matured clinical application experience.

  • FDA certification

    Pass American FDA certification in production quality management system, with quality control standard comparable with original research.

  • New crystal type patent advantages

    Low hygroscopicity, stable quality; good re-dissolving, quick solubility, and reduce the patient’s pain upon injection

  • Ease the patient’s financial burden

    National list of emergency drugs, and class B product of national medical insurance

  • Potential new indications

    Cerebral protection and peripheral organ protection

Medical evidence

Medical evidence

It is supported by many guides that, Valproate can be used for the prevention and treatment of epilepsy in perioperative period of neurosurgery, treatment of status epilepticus of neurology, and treatment of bipolar affective disorder of psychiatry.

  • Guidelines for the prevention and treatment of epilepsy during perioperative and post-traumatic Neurosurgery - draft

  • Expert consensus on the use of antiepileptic drugs after craniocerebral surgery

  • Guidelines for Clinical Treatment of Craniocerebral Trauma (4th Edition)

  • Expert consensus on critical care management in neurosurgery

  • Chinese Experts'Consensus on Monitoring and Treatment of Seizure Epilepsy Persistent State (Adult)

  • Guidelines for prevention and treatment of bipolar disorder in China

  • Guidelines for the Management of Severe Traumatic Brain Injury 4th Edition


Clinical application

Clinical application
  • Sodium valproate for injection, as a classical, safe and broad-spectrum antiepileptic drug, can control epileptic seizures rapidly through multiple action mechanisms, and has a good inhibitory effect on all types of epileptic seizures. At the same time, it is also a first-line mood stabilizer, which can be used to treat bipolar affective disorder and control mania and mania quickly. Schizophrenia with aggressive symptoms.

    Classic, Safe and Broad-spectrum
  • Double protection Brain Protection and Neuroprotection

    In animal models such as acute traumatic brain injury (TBI) rats, sodium valproate may play a protective role in the brain. At the same time, it may also play a neuroprotective role in several severe cases of acute CNS injury, such as stroke and brain trauma.

Clinical application of Department

  • Neurosurgery: immediate control, long-term benefits

    Preoperative intravenous injection of 15mg/kg (2-3 branches)
    Intraoperative: 15 mg/kg (2-3 branches) was intravenously injected before general anesthesia was stopped.
    Postoperative: 1 mg/kg/h maintenance (intravenous drip or intravenous pump, 3-4 branches), patients awake can be changed to oral tablets
    Time range: 5-7 days before operation to 7-12 days after operation
    Solvent: saline or glucose solution
    Time: intravenous injection > 5 min
    Concentration: <100mg/ml

    The first-line choice of epilepsy control during perioperative period and post-traumatic period in neurosurgery
  • Neurology: multiple mechanisms, rapid control

    Firstly, intravenous injection was used to achieve stable blood concentration quickly.
    Dose: 15-30 mg/kg (adult) 20-40 mg/kg (child)
    Speed: 3-6 mg/kg/min
    Concentration: <100mg/ml
    Solution: Glucose or saline
    After that, it was maintained by intravenous drip at the rate of 1 mg/kg/h.

    Non-sedative classical choice for termination of status epilepticus
  • Psychiatry Department

    Sodium valproate is a first-line mood stabilizer. It can be used in bipolar disorder and schizophrenic patients with excitement, agitation and violence.
    Relatively fast intravenous drip is allowed in the early stage of mania.
    Top Level Recommendation (Level 1)
    This product is a sodium valproate freeze-drying formulation. It works faster. When administered intravenously, it can reach a stable plasma concentration in a few minutes.
    Valproate is effective in the treatment of manic episodes of bipolar affective disorder, especially rapid circulation episodes and mixed episodes. It can prevent the recurrence of bipolar affective disorder.
    Intravenous infusion or intravenous drip of 0.9% saline for more than 24 hours, or intravenous drip of 0.9% saline for more than one hour in the maximum dose range (usually 20-30 mg/kg/day). When the effective blood concentration needs to be rapidly reached and maintained, intravenous infusion of 15mg < br /> kg is slowly carried out for more than 5 minutes.

    Front-line mood stabilizer for rapid control of mania and aggressive symptoms