Biqing ® (Sodium Valproate for Injection)
- Product name: Biqing ®
- Pharmacology category: Fatty acid antiepileptics
- Generic name: Sodium Valproate for Injection
- National list of emergency drugs, and class B product of national medical insurance
Indication indicationIndication indication
Product advantageProduct advantage
Multiple-mechanism control of epilepsy
Regulation γ－aminobutyric acid (GABA) energy system, ion channel
Have no liver enzyme induction effect, and fewer side effects
Broad-spectrum resistance to epilepsy
Control action in various epileptic diseases
It has been launched in the domestic market for 30 years, with rich and matured clinical application experience.
Pass American FDA certification in production quality management system, with quality control standard comparable with original research.
New crystal type patent advantages
Low hygroscopicity, stable quality; good re-dissolving, quick solubility, and reduce the patient’s pain upon injection
Ease the patient’s financial burden
National list of emergency drugs, and class B product of national medical insurance
Potential new indications
Cerebral protection and peripheral organ protection
Medical evidenceMedical evidence
It is supported by many guides that, Valproate can be used for the prevention and treatment of epilepsy in perioperative period of neurosurgery, treatment of status epilepticus of neurology, and treatment of bipolar affective disorder of psychiatry.
Guidelines for the prevention and treatment of epilepsy during perioperative and post-traumatic Neurosurgery - draft2006
Expert consensus on the use of antiepileptic drugs after craniocerebral surgery2012
Guidelines for Clinical Treatment of Craniocerebral Trauma (4th Edition)2015
Expert consensus on critical care management in neurosurgery2013
Chinese Experts'Consensus on Monitoring and Treatment of Seizure Epilepsy Persistent State (Adult)2014
Guidelines for prevention and treatment of bipolar disorder in China2007
Guidelines for the Management of Severe Traumatic Brain Injury 4th Edition2016
Clinical applicationClinical application
Sodium valproate for injection, as a classical, safe and broad-spectrum antiepileptic drug, can control epileptic seizures rapidly through multiple action mechanisms, and has a good inhibitory effect on all types of epileptic seizures. At the same time, it is also a first-line mood stabilizer, which can be used to treat bipolar affective disorder and control mania and mania quickly. Schizophrenia with aggressive symptoms.Classic, Safe and Broad-spectrum
Double protection Brain Protection and Neuroprotection
In animal models such as acute traumatic brain injury (TBI) rats, sodium valproate may play a protective role in the brain. At the same time, it may also play a neuroprotective role in several severe cases of acute CNS injury, such as stroke and brain trauma.
Clinical application of Department
Neurosurgery: immediate control, long-term benefits
Preoperative intravenous injection of 15mg/kg (2-3 branches)
Intraoperative: 15 mg/kg (2-3 branches) was intravenously injected before general anesthesia was stopped.
Postoperative: 1 mg/kg/h maintenance (intravenous drip or intravenous pump, 3-4 branches), patients awake can be changed to oral tablets
Time range: 5-7 days before operation to 7-12 days after operation
Solvent: saline or glucose solution
Time: intravenous injection > 5 min
Concentration: <100mg/mlThe first-line choice of epilepsy control during perioperative period and post-traumatic period in neurosurgery
Neurology: multiple mechanisms, rapid control
Firstly, intravenous injection was used to achieve stable blood concentration quickly.
Dose: 15-30 mg/kg (adult) 20-40 mg/kg (child)
Speed: 3-6 mg/kg/min
Solution: Glucose or saline
After that, it was maintained by intravenous drip at the rate of 1 mg/kg/h.
Non-sedative classical choice for termination of status epilepticus
Sodium valproate is a first-line mood stabilizer. It can be used in bipolar disorder and schizophrenic patients with excitement, agitation and violence.
Relatively fast intravenous drip is allowed in the early stage of mania.
Top Level Recommendation (Level 1)
This product is a sodium valproate freeze-drying formulation. It works faster. When administered intravenously, it can reach a stable plasma concentration in a few minutes.
Valproate is effective in the treatment of manic episodes of bipolar affective disorder, especially rapid circulation episodes and mixed episodes. It can prevent the recurrence of bipolar affective disorder.
Intravenous infusion or intravenous drip of 0.9% saline for more than 24 hours, or intravenous drip of 0.9% saline for more than one hour in the maximum dose range (usually 20-30 mg/kg/day). When the effective blood concentration needs to be rapidly reached and maintained, intravenous infusion of 15mg < br /> kg is slowly carried out for more than 5 minutes.
Front-line mood stabilizer for rapid control of mania and aggressive symptoms